2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W005130R
    2,4,6-Trihydroxybenzaldehyde (Standard) 487-70-7 98%
    2,4,6-Trihydroxybenzaldehyde is an orally active NF- B inhibitor. 2,4,6-Trihydroxybenzaldehyde shows anti-tumor activity, anti-cancer cell proliferative activity and anti-obesity activity.
    2,4,6-Trihydroxybenzaldehyde (Standard)
  • HY-W005627R
    Linoleyl alcohol (Standard) 506-43-4
    Linoleyl alcohol (Standard) is the analytical standard of Linoleyl alcohol. This product is intended for research and analytical applications. Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol.
    Linoleyl alcohol (Standard)
  • HY-W007319R
    Phenylpropiolic acid (Standard) 637-44-5 98%
    Phenylpropiolic acid is an endogenous metabolite. Phenylpropiolic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Phenylpropiolic acid (Standard)
  • HY-W007347R
    1,2-Cyclohexanedione (Standard) 765-87-7 98%
    1,2-Cyclohexanedione is an endogenous metabolite.
    1,2-Cyclohexanedione (Standard)
  • HY-W008188R
    3-Hydroxy-4-aminopyridine (Standard) 52334-53-9 98%
    3-Hydroxy-4-aminopyridine is an endogenous metabolite.
    3-Hydroxy-4-aminopyridine (Standard)
  • HY-W008343R
    1,3-Dimethyluracil (Standard) 874-14-6 98%
    1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively.
    1,3-Dimethyluracil (Standard)
  • HY-W008437R
    (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (Standard) 18835-59-1
    (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (Standard) is the analytical standard of (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (HY-W008437). This product is intended for research and analytical applications. (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate is an endogenous metabolite.
    (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (Standard)
  • HY-W008452R
    H-Tyr(3-I)-OH (Standard) 70-78-0 98%
    H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite.
    H-Tyr(3-I)-OH (Standard)
  • HY-W008642R
    Leu-Leu-OH (Standard) 3303-31-9 98%
    Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs.
    Leu-Leu-OH (Standard)
  • HY-W008766R
    H-Trp-NH2.HCl (Standard) 5022-65-1 98%
    H-Trp-NH2.HCl is an endogenous metabolite.
    H-Trp-NH2.HCl (Standard)
  • HY-W008848A
    DMT-L-dG(ib) Phosphoramidite 141846-56-2 98%
    DMT-L-dG(ib) Phosphoramidite (Compound 20D) is a nucleoside phosphoramidite that can be used for nucleotide assembly on solid supports.
    DMT-L-dG(ib) Phosphoramidite
  • HY-W008947R
    SEW​2871 (Standard) 256414-75-2 98%
    SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
    SEW​2871 (Standard)
  • HY-W009203R
    L-Cystine dihydrochloride (Standard) 30925-07-6 98%
    L-Cystine (dihydrochloride) (Standard) is the analytical standard of L-Cystine (dihydrochloride) (HY-W009203). This product is intended for research and analytical applications. L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones
    L-Cystine dihydrochloride (Standard)
  • HY-W009338R
    H-Val-Tyr-OH (Standard) 3061-91-4 98%
    H-Val-Tyr-OH is an endogenous metabolite.
    H-Val-Tyr-OH (Standard)
  • HY-W009993R
    3,4-Methylenedioxycinnamic acid (Standard) 2373-80-0 98%
    3,4-Methylenedioxycinnamic acid (Standard) is the analytical standard of 3,4-Methylenedioxycinnamic acid (HY-W009993). This product is intended for research and analytical applications. 3,4-Methylenedioxycinnamic acid is an inhibitor of the 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. 3,4-Methylenedioxycinnamic acid exhibits the Km value for the substrate ferulic acid of 4CL is 8.4 μM.3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid. 3,4-Methylenedioxycinnamic acid demonstrates larvicidal activity.
    3,4-Methylenedioxycinnamic acid (Standard)
  • HY-W010224R
    3-Amino-4-hydroxybenzoic acid (Standard) 1571-72-8 98%
    Vasicine (hydrochloride) (Standard) is the analytical standard of Vasicine (hydrochloride). This product is intended for research and analytical applications. Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity.
    3-Amino-4-hydroxybenzoic acid (Standard)
  • HY-W010248R
    2-Phenylglycine (Standard) 2835-06-5 98%
    2-Phenylglycine (Standard) is the analytical standard of 2-Phenylglycine (HY-W010248). This product is intended for research and analytical applications. 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period.
    2-Phenylglycine (Standard)
  • HY-W010271R
    (2S,3R,4S)-4-Hydroxyisoleucine (Standard) 55399-93-4 98%
    (2S,3R,4S)-4-Hydroxyisoleucine (Standard) is the analytical standard of (2S,3R,4S)-4-Hydroxyisoleucine (HY-W010271). This product is intended for research and analytical applications. (2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S)-4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S)-4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity.
    (2S,3R,4S)-4-Hydroxyisoleucine (Standard)
  • HY-W010410S
    Oct-1-en-3-ol-d3 1335435-98-7 98%
    Oct-1-en-3-ol-d3 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities.
    Oct-1-en-3-ol-d3
  • HY-W010448R
    Imidazol-1-yl-acetic acid (Standard) 22884-10-2 98%
    Imidazol-1-yl-acetic acid (Standard) is the analytical standard of Imidazol-1-yl-acetic acid. This product is intended for research and analytical applications. Imidazol-1-yl-acetic acid is an endogenous metabolite.
    Imidazol-1-yl-acetic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity